The Research Associate provides hands-on experimental support for base editing workflows (ABE/CBE) across genome engineering programs. This role is responsible for executing experiments, generating high-quality data, and supporting workflow optimization within the Genome Engineering Technology (GET) team. The position works closely with the Base Editing Manager and cross-functional partners to advance genome editing strategies for species restoration. This is an individual contributor role that reports to the Base Editing Manager. This position will be based on-site in Dallas, TX. Relocation assistance is available. <h3>Duties and Responsibilities:</h3><ul><li>Execute base editing experiments (ABE, CBE) in mammalian cell systems</li><li>Perform cell culture, including transfection, passaging, and cryopreservation</li><li>Prepare and handle base editing reagents, including guides and plasmids</li><li>Conduct nucleic acid extractions and downstream editing outcome analyses (e.g., PCR, sequencing, flow cytometry)</li><li>Support optimization of editing efficiency, specificity, and delivery methods</li><li>Maintain accurate experimental records in Benchling (ELN)</li><li>Assist with reagent inventory management and lab organization</li><li>Collaborate with genome engineering teams to support project execution</li><li>Troubleshoot experimental workflows and contribute to protocol improvements</li></ul><h3>Required Skills and Abilities:</h3><ul><li>Experience with mammalian cell culture and cell-based assays</li><li>Proficiency in molecular biology techniques (PCR, DNA/RNA handling, cloning)</li><li>Familiarity with genome editing technologies (CRISPR, base editing preferred)</li><li>Experience with flow cytometry or cell characterization methods is a plus</li><li>Strong attention to detail and commitment to high-quality documentation</li><li>Ability to manage multiple priorities and work in a fast-paced environment</li><li>Strong communication and collaboration skills</li></ul><h3>Education and Experience:</h3><ul><li>Bachelor’s or Master’s degree in Molecular Biology, Genetics, Bioengineering, or related field</li><li>1 or more years of relevant laboratory experience (industry or academic)</li><li>Hands-on experience with cell culture and molecular biology required</li></ul><div>What Colossal Offers Full-Time Employees:<ul><li style="font-weight:400;">Medical, dental, and vision coverage</li><li style="font-weight:400;">Excellent paid time off and company holidays so you can rest and recharge </li><li style="font-weight:400;">Flexible spending accounts (FSA)</li><li style="font-weight:400;">Company matched 401k retirement plan</li><li style="font-weight:400;">Paid parental leave at 100% salary for up to 12 weeks</li><li style="font-weight:400;">Education reimbursement </li><li style="font-weight:400;">An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. <a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law </a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. Colossal is proud to be named a Best Place to Work by BuiltIn for 4 years in a row across multiple categories in 2023, 2024, 2025, and 2026:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024, 2025, and 2026.</li></ul> <a href="https://builtin.com/awards/dallas/2026/best-places-to-work">Built In 2026 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces! <img style="max-width:100%;" src="https://employers.builtin.com/wp-content/uploads/2023/09/2024BPTW_GeneralBadgeYear_AllWhite-1-281x300.png">   <img style="max-width:100%;" src="https://www.greatplacetowork.com/images/profiles/7049203/companyBadge.png?20240207">     <img style="max-width:100%;" src="https://pbs.twimg.com/media/FvJDPn0aEAAwgAH?format=jpg&amp;name=small">     <img style="max-width:100%;" src="https://imageio.forbes.com/dam/imageserve/65e730dcd08766cc9dbcdb47/x.jpg?format=jpg&amp;height=183&amp;width=255&amp;fit=bounds"> <img style="max-width:100%;" src="https://drive.google.com/file/d/1OfyDuXFTNF7LBhvIuV9E605m7rOrdizP/view?usp=drive_link"> </div>

The science of genetics. The business of discovery.
Colossal is a breakthrough bioscience and genetic engineering company that builds radical new technologies to advance the field of genomics. Colossal creates disruptive technologies for extinct species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth. The company is the first to apply CRISPR technology for the purposes of species de-extinction, beginning with the woolly mammoth. Colossal is accepting humanity&rsquo;s duty to restore Earth to a healthier state, while also solving for the future economies and biological necessities of the human condition through cutting-edge science and technologies.

Research Associate, Genome Engineering

The Research Associate provides hands-on experimental support for base editing workflows (ABE/CBE) across genome engineering programs. This role is responsible for executing experiments, generating high-quality data, and supporting workflow optimization within the Genome Engineering Technology (GET) team. The position works closely with the Base Editing Manager and cross-functional partners to advance genome editing strategies for species restoration. This is an individual contributor role that reports to the Base Editing Manager. This position will be based on-site in Dallas, TX. Relocation assistance is available. <h3>Duties and Responsibilities:</h3><ul><li>Execute base editing experiments (ABE, CBE) in mammalian cell systems</li><li>Perform cell culture, including transfection, passaging, and cryopreservation</li><li>Prepare and handle base editing reagents, including guides and plasmids</li><li>Conduct nucleic acid extractions and downstream editing outcome analyses (e.g., PCR, sequencing, flow cytometry)</li><li>Support optimization of editing efficiency, specificity, and delivery methods</li><li>Maintain accurate experimental records in Benchling (ELN)</li><li>Assist with reagent inventory management and lab organization</li><li>Collaborate with genome engineering teams to support project execution</li><li>Troubleshoot experimental workflows and contribute to protocol improvements</li></ul><h3>Required Skills and Abilities:</h3><ul><li>Experience with mammalian cell culture and cell-based assays</li><li>Proficiency in molecular biology techniques (PCR, DNA/RNA handling, cloning)</li><li>Familiarity with genome editing technologies (CRISPR, base editing preferred)</li><li>Experience with flow cytometry or cell characterization methods is a plus</li><li>Strong attention to detail and commitment to high-quality documentation</li><li>Ability to manage multiple priorities and work in a fast-paced environment</li><li>Strong communication and collaboration skills</li></ul><h3>Education and Experience:</h3><ul><li>Bachelor’s or Master’s degree in Molecular Biology, Genetics, Bioengineering, or related field</li><li>1 or more years of relevant laboratory experience (industry or academic)</li><li>Hands-on experience with cell culture and molecular biology required</li></ul><div>What Colossal Offers Full-Time Employees:<ul><li>Medical, dental, and vision coverage</li><li>Excellent paid time off and company holidays so you can rest and recharge </li><li>Flexible spending accounts (FSA)</li><li>Company matched 401k retirement plan</li><li>Paid parental leave at 100% salary for up to 12 weeks</li><li>Education reimbursement </li><li>An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. <a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law </a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. Colossal is proud to be named a Best Place to Work by BuiltIn for 4 years in a row across multiple categories in 2023, 2024, 2025, and 2026:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024, 2025, and 2026.</li></ul> <a href="https://builtin.com/awards/dallas/2026/best-places-to-work">Built In 2026 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!                </div>

Research Associate, Genome Engineering

About the Job

About the Company

Colossal Biosciences

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